Endocrine Abstracts

Langerhans cell Histiocytosis is a rare neoplastic histiocytic disorder. It has broad spectrum of clinical presentations from single system to multi system. It mainly affects children but can occur in adults. It can present with skin lesions, skull/jaw tumours, polyuria/polydipsia, fever, cough and dyspnea, bone pain, ataxia etc. 25% of adult cases involve Pituitary (anterior and posterior pituitary gland) and hypothalamus. BRAF and MAP2K1 mutations are most ...

Introduction: Causes of hypophosphataemia include reduced intestinal absorption, inadequate intake, transcellular shifts (refeeding syndrome, glucose/insulin infusion), renal loss which is either FGF23 mediated (inherited forms or tumour induced osteomalacia) or non-FGF23 mediated (hyperparathyroidism, drugs)Case report: We present a case of 51 years old female referred to us with multiple fractures during her half marathon. She suffered from bilateral m...

Introduction: Endocrine dysfunctions are a well known side effect of Immunotherapy with check point inhibitors. Endocrine dysfunction can begin as early as 6 days post initiation of therapy. There is a growing consensus that prompt recognition and early management of these endocrinopathies is essential; however there is a lack of specific guidelines regarding the monitoring of endocrine function. We present a case report of an asymptomatic patient known to have renal cell canc...

It is very rare to have Pituitary metastasis in Renal Cell cancer (RCC). Prevalence of Pituitary metastasis varies from 1-4% in all cancers and about 2.6% in RCC. Most common cancers with pituitary metastasis are breast (33%) and lung (36%). We present a rare case of RCC with pituitary Metastasis presented with severe Hyponatraemia. A 71 years old male with history of renal cell cancer who underwent Right nephrectomy in 2017. He was found to have intrathoracic metastases in 20...

Introduction: Survivors of childhood, adolescent or young adult cancers are at risk of endocrine dysfunction from their tumours, surgery, chemotherapy and/or radiotherapy treatment. The hypothalamic pituitary axes and gonads are at risk of dysfunction depending on a number of risk factors. Endocrine dysfunction can occur from before diagnosis of cancer, soon after but mostly a number of years later, even after survivors have been discharged from oncology follow-up. We aim to e...

Parathyroid hormone is a polypeptide consisting of 84 amino acids. Quantification of circulating intact PTH assists in the differential diagnosis of hypercalcemia. It is important to interpret PTH results with caution and to keep in mind Immunoassays interference can also be a reason of falsely high PTH levels. We present an interesting case referred with high parathyroid hormone levels. A 74 years old female attended clinic with raised PTH levels of 11.7 pmol/l, a normal calc...

Background: Acromegaly is a rare condition characterised primarily by tumourous production of excess Growth Hormone (GH) from a pituitary adenoma. Clinical management aims at normalising serum IGF1 levels within sex and age-adjusted reference parameters. Treatment options include pituitary surgery, medical therapy with somatostatin analogue (SSA), cabergoline, pegvisomant or radiotherapy. A combination of treatment modalities is common for the majority of patients.<p class...

Introduction: This audit was undertaken to determine whether Primary Hyperparathyroidism (PHPT) management in the clinical setting is compliant with the nine standards set of the existing PHPT pathway in the City Hospital Sunderland Foundation Trust (CHSFT). PHPT pathway was developed in (CHSFT) to allow effective management and surgical referral for this common condition in line with available national and international guidelines.Methods: Data was retr...